 Tizanidine is an alpha-2 adrenergic receptor agonist (muscle relaxant)
used to relax tense and rigid muscles caused by spasticity, by temporarily
relaxing muscle tone and to treat spasms, cramping and tightness of
muscles caused by medical problems such as multiple sclerosis or spinal
cord injuries. Tizanidine does not cure these disorders, but is used short
term so that exercise and physical therapy can be undertaken. Tizanidine acts on the central
nervous system (CNS) by blocking communication among nerves in the brain and spinal cord.
Tizanidine is also sometimes used for low back pain and headaches caused by muscle tension.
Brand names include: Sirdalud and Zanaflex. It is also sold as the generic and in combination with the painkiller Ibuprofen, as: Tizafen, Fenatiz and Bruzen MR (Tizanidine with Ibuprofen).
Ordering options for Tizanidine, including Sirdalud, Zanaflex and Tizafen are below.
No prescription is needed, but some pharmacies will require a consultation via questionnaire to
enable their staff physician to issue a prescription (this is a free consultation).
Other pharmacies do not require a consultation (no consultation needed)*
Precautions before taking Tizanidine:
Do not Tizanidine if you are allergic to tizanidine or are taking either of the following drugs:
Fluvoxamine (Luvox) an antidepressant or Ciprofloxacin (Cipro) an antibiotic.
Inform your doctor about any of the following:
About ALL drugs that you take, as many other drugs may adversely interact with Tizanidine.
If you have or have ever had kidney or liver disease, high or low blood pressure or a history of
Long QT syndrome or if you are pregnant or plan to become pregnant as you may not be able
to take Tizanidine or made need a dosage adjustment or special tests.
Tizanidine Common Side Effects
Tizanidine may sometimes cause side effects, such as:
drowsiness, dizziness, nervousness
stomach pain, diarrhea, constipation, vomiting
muscle weakness, back pain
skin rash, sweating.
If you experience any of the following serious side effects, call your doctor immediately:
allergic reactions, difficulty breathing, hives, swelling of the face, lips, tongue, or throat.
light-headedness, fainting and slow heart rate
hallucinations, confusion, unusual thoughts or behavior
nausea, stomach pain, loss of appetite,
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
burning or pain during urination
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